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氨氯地平和贝那普利治疗肾性高血压患者动脉硬化的疗效比较

Effect of amlodipine versus benazepril in treatment of arteriosclerosis in patients with renal hypertension

    摘要
  • 摘要:
      目的  比较氨氯地平和贝那普利对肾性高血压患者动脉硬化的治疗效果差异。
      方法  将175例肾性高血压患者随机分为2组, A组94例患者服用苯磺酸氨氯地平片5~10 mg, 1次/d, B组81例患者服用贝那普利片10~20 mg, 1次/d。治疗前及治疗8个月后，检测受试者的血压水平和动脉硬化指标臂踝脉搏波传导速度(baPWV)、踝臂指数(ABI)水平。
      结果  治疗后, 2组血压均较治疗前下降，差异有统计学意义(P < 0.05); 2组治疗前后血压比较，差异均无统计学意义(P>0.05)。治疗后, B组baPWV较治疗前下降, ABI较治疗前升高，差异有统计学意义(P < 0.05); A组治疗后的baPWV、ABI与治疗前比较，差异无统计学意义(P>0.05)。
      结论  相较氨氯地平，贝那普利治疗肾性高血压所致的动脉硬化有更好的效果。

     

    Abstract:
      Objective  To investigate the effect of amlodipine versus benazepril in treatment of arteriosclerosis in patients with renal hypertension.
      Methods  One hundred and seventy-five patients with renal hypertension in our hospital were randomly divided into two groups. Group A(n=94) received amlodipine for 5~10 mg once a day, and group B(n=81) received benazepril for 10~20 mg once a day. Blood pressure and arteriosclerosis indicators including brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were measured before and after 8 months of anti-hypertensive therapy.
      Results  The blood pressure after treatment of both groups significantly decreased compared with before treatment (P < 0.05), while there were no significant between-group differences in blood pressures before and after treatment(P>0.05). After treatment, baPWV of B group was significantly lower, ABI was significantly higher than that before treatment (P < 0.05), but no significant differences were found in abore indicators before and aftertreatment in A groups(P>0.05).
      Conclusion  Benazepril has better effect in treatment of arteriosclerosis caused by renal hypertension than amlodipine.

     

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