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宫颈癌根治术后高危型人乳头瘤病毒、鳞状细胞癌抗原及鳞状细胞癌相关抗原检测对宫颈癌复发的预测价值

Value on detection of high-risk human papilloma virus, squamous cell carcinoma antigen and squamous cell associated carcinoma antigen after radical resection of cervical cancer

    摘要
  • 摘要:
      目的  探讨宫颈癌根治术后高危型人乳头瘤病毒(HR-HPV)、鳞状细胞癌抗原(SCC-Ag)及鳞状细胞癌相关抗原(SCCA)水平检测在预测宫颈癌复发的价值。
      方法  选择50例宫颈癌患者，所有患者术后第1~2年内每3个月进行1次随访，术后第2~5年内每半年进行1次随访。随访时对患者的HR-HPV、SCC-Ag、SCCA水平进行检测，分析其预测复发的价值。
      结果  5例宫颈癌术后复发患者HR-HPV与SCC-Ag阳性率显著高于未复发患者(P < 0.05)。复发患者血清SCCA的表达水平阳性率显著高于未复发患者(P < 0.05)。
      结论  宫颈癌根治术后HR-HPV、SCC-Ag、SCCA联合检测在宫颈癌辅助诊断、疗效评估以及预后监测方面具有重要的临床参考价值。

     

    Abstract:
      Objective  To study the value of high-risk human papilloma virus (HR-HPV), squamous cell carcinoma antigen (SCC-Ag) and squamous cell carcinoma associated antigen (SCCA) levels after radical operation of cervical cancer.
      Methods  A total of 50 patients with cervical cancer were selected as study subjects, and were followed up every 3 months within 1 to 2 years and every 6 months within 2 to 5 years after surgery. During follow-up, HR-HPV, SCC-Ag and SCCA levels of patients were detected, and their value in prediction of recurrence was explored.
      Results  The positive rates of HR-HPV and SCC-Ag in 5 recurrence patients after operation were significantly higher than those without recurrence (P < 0.05). The positive rate of serum SCCA in recurrence patients was significantly higher than those without recurrence(P < 0.05).
      Conclusion  The combined detection of HR-HPV, SCC-Ag and SCCA after radical resection of cervical cancer is of great value in assistant diagnosis, curative effect evaluation and prognosis monitoring of cervical cancer.

     

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