Objective  To analyze the incidence and influencing factors of adverse reactions caused by intravenous infusion of moxifloxacin in our hospital within 5 years.

  Methods  Patients who received antibiotic therapy with moxifloxacin intravenous infusion were enrolled, and the occurrence of adverse reactions was analyzed. Descriptive statistic analysis were performed on the patient's gender, age, adverse reactions involving system or organ and clinical manifestations, and adverse reactions. Pearson′s chi-square test was performed on the correlation between adverse reaction rates and gender, age, and drug classes.

  Results  Of the 6 222 patients, 106 had adverse reactions, with its incidence of 1.70%, among whom 7 occurred serious adverse reactions. Adverse reactions mainly involved in the digestive system, skin, and neuropsychiatric system, accounting for 32.08%, 28.30%, and 20.75%, respectively. There were 2 cases with QTc interval prolonging and 1 case with allergic reaction in this group. The incidence of adverse reactions caused by intravenous infusion of moxifloxacin was not associated with elder, middle and young age, drug types of original drugs and generic drugs, but showed significant correlation with gender (P < 0.01).

  Conclusion  Medical staff should inquire and master the patient′s medical history and history of fluoroquinolone medication when using moxifloxacin, strengthen drug monitoring so as to improve its rationality and safety.