Objective  To explore the effect of early application of low molecular weight heparin calcium on the prevention of coagulation dysfunction in patients with respiratory failure.

  Methods  A total of 92 patients with respiratory failure were randomly divided into two groups, with 46 cases in each group. The patients in both groups were given regular treatment, such as cough relief, expectoration, asthma relief, mechanical ventilation and low flow oxygen inhalation. On this basis, the study group was given hypodermic injection of low molecular weight heparin calcium. The blood gas analysis indexes before and after treatment were compared between two groups, including pH value, partial pressure of arterial carbon dioxidep(CO₂) and partial pressure of arterial blood oxygenp(O₂). The coagulation function including partial thromboplastin time (APTT), prothrombin time (PT), D-Dimer (D-D), platelet (PLT) of the two groups before and after treatment was compared.

  Results  After treatment, the pH, p(CO₂) and p(O₂) levels of the two groups significantly improved, and the pH, p(CO₂) and p(O₂) levels of the study group were significantly higher than those of the control group (P < 0.05). After treatment, APTT, PT, D-D and PLT in both groups significantly improved when compared with those before treatment, and APTT, PT, D-D and PLT in the study group were significantly better than those in the control group (P < 0.05).

  Conclusion  Early application of low molecular weight heparin calcium is effective and safe in the treatment of respiratory failure, which can improve the coagulation function and blood gas indexes, reduce the rate of thrombosis, and promote the improvement of disease condition.