Objective  To study the clinical efficacy of strontium-89 (⁸⁹Sr) combined with salmon calcitonin spray in the treatment of malignant tumors patients with bone metastatic pain.

  Methods  A total of 129 advanced malignant tumors patients with bone metastases were divided into study 1 group, study 2 group and control group. Study 1 group (n=43)was treated with ⁸⁹Sr combined with salmon calcitonin spray as well as physician-nursing education, and study 2 (n=43) was treated with ⁸⁹Sr combined with salmon calcitonin spray, while the control group (n=43) was only treated with ⁸⁹Sr. The therapeutic effects on pain and bone metastases, changes in blood strontium and calcium levels were compared between the three groups. After 6 months of treatment, Symptom Checklist-90(SCL-90), General Hospital Anxiety/Depression Scale(HADS) and Family Assessment Device(FAD) were used to measure the conditions of patients.

  Results  After treatment, the effective rate of pain treatment in study 1 group was higher than that in study 2 group, which was higher than that in control group (P < 0.05); the effective rate of bone metastasis treatment was highest in study 1 group, and lowest in the control group (P < 0.05); the concentrations of blood strontium and calcium were the lowest in study 1 group and highest in the study 1 group(P < 0.05). The scores of SCL-90 was the lowest in the study 1 group, and highest in control group (P < 0.05). The incidence of anxiety and depression in study 1 group was lower than that in study 2 group and control group (P < 0.05), but there was no difference between study 2 group and control group (P>0.05); the proportions of patients with moderate and severe anxiety and depression and their scores ≥8 points in study 1 group was lower than that in study 2 group that was lower than that of the control group at the same time(P < 0.05); the item scores of FAD in study 1 group were lower than that of study 2 (P < 0.05), but there was no difference between study 2 group and the control group (P>0.05).

  Conclusion  Strontium 89 combined with salmon calcitonin nasal spray and medical and nursing education has obvious curative effect on bone metastasis and bone pain of malignant tumors, which has certain clinical popularization value.