Objective  To investigate the clinical efficacy of bromohexine combined with azithromycin in the treatment of bronchial pneumonia in children and its effect on C reactive protein (CRP) and procalcitonin (PCT).

  Methods  A total of 86 children with bronchopneumonia admitted to pediatric department were randomly divided into routine group (n=43) and combined group (n=43). All the children were given basic treatment and nursing measures. The routine group was treated with azithromycin, and the combined group was treated with bromhexine and azithromycin, and the treatments of two groups lasted for 4 to 12 days. The disappearance time of symptoms and signs was recorded, and the clinical efficacy and safety were compared between the two groups. The levels of serum inflammatory factors CRP, PCT were measured before and after treatment.

  Results  The disappearance time of fever, cough and lung moist rales in the combined group was shorter than that in the conventional group (P < 0.05), and the total clinical effective rate in the combined group was significantly higher than that in the routine group (97.67% vs. 83.72%, P < 0.05). After treatment, the levels of serum CRP, PCT of the two groups decreased significantly (P < 0.05), and compared with the routine group, the levels of CRP, PCT in the combined group were significantly lower (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).

  Conclusion  Bromhexine combined with azithromycin can effectively alleviate the symptoms and signs of children with bronchopneumonia and reduce the levels of serum inflammatory factors such as CRP and PCT.