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帕瑞昔布钠和氟比洛芬酯应用于重症肌无力胸腺切除术后镇痛的效果比较

Effect of parecoxib sodium versus flurbiprofenaxetil in analgesia after thymectomy for patients with myasthenia gravis

    摘要
  • 摘要:
      目的  比较帕瑞昔布钠与氟比洛芬酯运用于重症肌无力患者胸腺切除术后镇痛的效果。
      方法  选取重症肌无力胸腺切除术患者118例作为研究对象，根据术后镇痛方式的不同将其分为观察组60例与对照组58例。对照组在手术结束后静脉缓慢滴注氟比洛芬酯，观察组在手术结束后静脉滴注帕瑞昔布钠，观察2组患者术后1、2、6、12、24 h静息及运动状况下VAS评分情况，并观察2组患者术前与术后1、2、6、12、24 h的平均动脉压(MAP)、心率(HR)、呼吸频率(RR)、血氧饱和度(SpO2)情况以及术后不良反应发生情况。
      结果  2组患者在静息状态下、运动状态下的组内不同时点VAS评分比较，差异均有统计学意义(P < 0.05);观察组术后各时点静息状态下、运动状态下的VAS评分均显著低于对照组(P < 0.05)。2组MAP、HR、RR、SpO2指标不同时点组内比较，差异均有统计学意义(P < 0.05), 但2组间各指标水平无显著差异(P>0.05)。观察组术后不良反应总发生率显著低于对照组(P < 0.05)。
      结论  帕瑞昔布钠应用于重症肌无力患者胸腺切除术后镇痛中具有显著效果。

     

    Abstract:
      Objective  To compare the effect of parecoxib sodium versus flurbiprofen axetil in analgesia after thymectomy for patients with myasthenia gravis.
      Methods  A total of 118 patients undergoing thymectomy for patients with myasthenia gravis were selected as the study subjects. According to the different ways of postoperative analgesia, they were divided into group A (60 cases) and group B (58 cases). The control group received intravenous drip of flurbiprofen axetil slowly after operation, while the observation group received intravenous drip of parecoxib sodium after the operation. The VAS scores of two groups at 1, 2, 6, 12 h of resting and exercising after operation were observed. The mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), blood oxygen saturation (SpO2) and occurrence of adverse reactions were observed at 1, 2, 6, 12 and 24 h before and after operation.
      Results  There were significant differences at different time points at rest and exercising in VAS scores in the same group (P < 0.05), and the observation group was significantly higher than that in the control group in above time points(P < 0.05). The levels of MAP, HR, RR at different time points in the same group showed significant difference(P < 0.05), but showed no between-group difference (P>0.05). The incidence of postoperative adverse reactions in observation group was significantly lower than that in control group (P < 0.05).
      Conclusion  Parecoxib sodium has a significant effect in analgesia after thymectomy for patients with myasthenia gravis.

     

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