Objective  To investigate the application of 2%chlorhexidine glucose combined with early anal closure in prevention of perineal incision infection in Miles surgery.

  Methods  A total of 62 patients who underwent Miles surgery in our hospital were divided into observation group (32 cases) and control group (30 cases). The control group was given routine preoperative preparation and intraoperative routine surgery, while the observation group was given 2%chlorhexidine glucose to scrub the perineum at 3 days before operation, and the anus was closed immediately after the operation. The incidence of postoperative incision infection rate was compared between the two groups.

  Results  The infection rate of postoperative perineal incision was 6.3% (2/32) in the observation group, which was significantly lower than 30.0% (9/30) in the control group(P < 0.05). The antibiotic use time and hospital stay in the observation group were significantly shorter, the hospitalization expenses was significantly lower, and the nursing satisfaction was significantly higher than that in the control group (P < 0.05).

  Conclusion  Routine preparation at 3 days before surgery combined with 2%chlorhexidine glucose to scrub the perineum, immediately close of anus after anaesthesia and disinfection during the operation can effectively reduce the incidence of postoperative incision infection, and effectively prevent perineal incision infection after Miles surgery. At the same time, it can effectively shorten postoperative antibiotic use time and length of hospital stay, reduce the total hospital expense of hospital stay, and improve patients′satisfaction.