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补肾清热汤联合中药外敷治疗肾虚湿热型强直性脊柱炎的效果观察

Efficiency observation of Bushen Qingre Decoction combined with external application of traditional Chinese medicine in the treatment of patients with ankylosing spondylitis differentiated as type of kidney deficiency and dampness-heat

    摘要
  • 摘要:
      目的  探讨补肾清热汤联合中药外敷治疗肾虚湿热型强直性脊柱炎的临床效果。
      方法  将50例强直性脊柱炎患者随机分为观察组与对照组, 每组25例。对照组采用西药治疗，观察组在对照组基础上采用补肾清热汤联合中药外敷治疗。比较2组患者治疗前后的红细胞沉降率(ESR)与C反应蛋白(CRP)水平、晨僵时间、Schober试验、视觉模拟评分法(VAS)评分、指地距、中医症候积分、疗效以及不良反应发生率。
      结果  观察组总有效率显著高于对照组(P < 0.05)。治疗后, 2组的晨僵时间、VAS评分、指地距和中医症候积分均显著降低(P < 0.05), Schober试验结果显著提高(P < 0.05), 且观察组上述指标较对照组变化更显著(P < 0.05)。治疗后，观察组ESR、CRP水平显著低于对照组(P < 0.05)。2组不良反应发生率比较，差异无统计学意义(P>0.05)。
      结论  与单纯西药治疗相比，在西药治疗的基础上，补肾清热汤联合中药外敷治疗肾虚湿热型强直性脊柱炎的疗效显著，可改善患者中医症候积分与机体炎症因子水平。

     

    Abstract:
      Objective  To explore the clinical effect of Bushen Qingre Decoction combined with external application of traditional Chinese medicine in the treatment of patients with ankylosing spondylitis differentiated as type of kidney deficiency and dampness-heat.
      Methods  Totally 50 patients with ankylosing spondylitis were randomly divided into observation group (n=25) and control group (n=25). The control group was treated with western medicine, while the observation group was treated with Bushen Qingre Decoction combined with external application of traditional Chinese medicine on the basis of the control group. The erythrocyte sedimentation rate (ESR) and C reaction protein (CRP), morning stiffness time, the Schober test, Visual Analogue Scale (VAS) score, finger-to-ground distance, score of TCM symptoms before and after treatment as well as efficiency and incidence rate of complications were compared between the two groups.
      Results  The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, morning stiffness time, VAS score, finger-to-ground distance and score of TCM symptom in both groups reduced significantly (P < 0.05), the Schober test results improved significantly (P < 0.05), and the changes of the above indicators in the observation group were significantly greater than those in the control group (P < 0.05). After treatment, the levels of ESR and CRP in the observation group were significantly lower than those in the control group (P < 0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).
      Conclusion  Compared with western medicine, implementation of Bushen Qingre Decoction combined with external application of traditional Chinese medicine on the basis of Western medicine shows a significant effect in treatment of patients with ankylosing spondylitis differentiated as type of kidney deficiency and dampness-heat, which can improve the scores of TCM symptoms and the levels of inflammatory factors.

     

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