Objective  To analyze the efficacy of Qingyi Chengqi Decoction combined with heterozygous blood purification in the treatment of patients with acute severe pancreatitis (ASP).

  Methods  Eighty-six patients with ASP were randomly divided into two groups, with 43 cases in each group. The control group was treated with heterozygous blood purification, while the observation group was given Qingyi Chengqi Decoction combined with heterozygous blood purification. Total effective rate, indicators of symptoms and signs improvement abdominal pain disappearance time, time of blood amylase (AMS) return to normal, time of white blood cell recovery, hospitalization time, serum AMS level, intra-abdominal pressure (IAP), serum inflammation factors C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) levels were compared between two groups.

  Results  The total effective rate of the observation group was 93.02%, which was significantly higher than 72.09% of the control group (P < 0.05). The disappearance time of abdominal pain, the time of blood AMS return to normal, the time of white blood cell recovery and the hospitalization time in the observation group were significantly shorter than those in the control group (P < 0.05). Serum AMS and IAP levels at 1, 3 and 5 days after treatment in the observation group were significantly lower than those in the control group (P < 0.05). The serum CRP and TNF-α levels at 1, 3 and 5 days after treatment in the observation group were significantly lower than those in the control group (P < 0.05).

  Conclusion  Qingyi Chengqi Decoction combined with heterozygous blood purification can effectively control the inflammatory reaction of ASP patients, alleviate the clinical symptoms and shorten the hospital stay.