Objective  To investigate the effect of dezocine injection combined with dexmedetomidine on the postoperative pain and quality of life in patients with advanced liver cancer.

  Methods  A total of 64 patients with advanced liver cancer were selected and randomly divided into experimental group and control group, with 32 cases in each group. The control group was anesthetized with remifentanil during operation, while the experimental group was anesthetized with dzocine combined with dexmedetomidine on the basis of the control group. The extubation time, recovery time, orientation recovery time and pain degrees at 2, 6 and 24 hours after operation were compared between two groups. The scores of dimensions of SF-36 before operation and 7 days after operation were compared between two groups. The incidence rate of adverse reactions within 24 hours after operation was compared between the two groups.

  Results  The Visual Analogue Scale (VAS) scores of the experimental group at 2, 6 and 24 hours after operation were significantly lower than those of the control group (P < 0.05). The extubation time, recovery time and orientation recovery time of the experimental group were significantly shorter than those of the control group (P < 0.05). Before operation, there were no significant differences in the scores of dimensions of SF-36 between the two groups (P>0.05). After operation, the scores of physical function, psychological function and life function increased significantly in both groups (P < 0.05), and the scores of dimensions of SF-36 in the experimental group were significantly higher than those in the control group (P < 0.05). The incidence of postoperative adverse reactions in the experimental group was significantly lower than that in the control group (P < 0.05).

  Conclusion  Dezocine injection combined with dexmedetomidine can significantly alleviate postoperative pain in patients with advanced liver cancer, shorten the recovery time and improve the quality of life.