Objective  To investigate the effect of oral administration of aspirin and lipitor in combination for patients with different types of carotid plaques.

  Methods  A total of 80 patients with carotid artery plaques in our hospital were divided into soft plaque group (n=45), mixed type plaque group(n=16)and hard plaque group (n=19). Patients of three groups were given oral administration of aspirin and lipitor in combination. The plaque size, serum inflammatory index and blood lipid of the three group before treatment and 6, 12 months after treatment were compared.

  Results  Compared with before treatment, soft plaque group and mixed plaque group were significantly smaller at 6 and 12 months after treatment (P < 0.05), and the outcomes at 12 months was better than at 6 months, but the size of hard plaque group has no obvious change(P>0.05). Compared with before treatment, the serum hypersensitive C reactive protein (hs-CRP), plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) at 6 and 12 months after treatment of three groups were significantly decreased, but high-density lipoprotein (HDL-C) was increased(P < 0.05), and the results of at 12 months after treatment was better than that at 6 months after treatment.

  Conclusion  Combined oral administration of aspirin and lipitor can significantly reduce the soft and mixed type of carotid artery plaques, and it can improve patients′serum inflammatory reaction and lipid levels, but the effect of hard plaques treatment is not obvious.