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益气养心活血方对气阴两虚兼血瘀型心绞痛患者血脂及血液流变学水平的影响

Effect of Yiqi Yangxin Huoxue Recipe on blood lipid and hemorheological level in patients with angina pectoris differentiated as type of deficiency of Qi and Yin complicated with blood stasis

    摘要
  • 摘要:
      目的  探讨益气养心活血方对气阴两虚兼血瘀型心绞痛患者血脂及血液流变学水平的影响。
      方法  选取气阴两虚兼血瘀型心绞痛患者126例，按随机数字表法分为试验组(n=63)与对照组(n=63)。对照组予以常规西医治疗，试验组在常规西医治疗基础上联合益气养心活血方治疗。比较2组临床疗效、心电图疗效、不良反应，治疗前、治疗1个月后中医症状积分、血脂指标高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、血液流变学指标血浆黏度、红细胞比容(HCT)、红细胞聚集指数(EAI)水平。
      结果  试验组治疗1个月后临床疗效及心电图疗效均显著优于对照组(P < 0.05)。治疗1个月后, 2组中医症状积分较治疗前显著降低，且试验组显著低于对照组(P < 0.05)。治疗1个月后, 2组HDL-C水平较治疗前显著升高，LDL-C、TG、TC水平较治疗前显著降低，且试验组显著优于对照组(P < 0.05)。治疗1个月后, 2组血浆黏度、HCT、EAI水平较治疗前显著降低，且试验组显著低于对照组(P < 0.05)。试验组不良反应发生率9.52%, 与对照组7.94%比较，差异无统计学意义(P>0.05)。
      结论  益气养心活血方可有效缓解气阴两虚兼血瘀型心绞痛患者临床症状，改善血脂代谢与血液流变学。

     

    Abstract:
      Objective  To investigate the effect of Yiqi Yangxin Huoxue Recipe on blood lipid and hemorheological level in patients with angina pectoris differentiated as type of deficiency of Qi and Yin complicated with blood stasis.
      Methods  A total of 126 patients with angina pectoris differentiated as type of deficiency of Qi and Yin complicated with blood stasis were selected and randomly divided into experimental group (n=63) and control group (n=63). The control group was treated with conventional western medicine, while the experimental group was treated with Yiqi Yangxin Huoxue Decoction on the basis of control group. The clinical efficacy, electrocardiogram efficacy and adverse reactions of the two groups were compared. The scores of TCM symptoms, blood lipid indexes high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), hemorheological indexes plasma viscosity, hematocrit (HCT), erythrocyte aggregation index (EAI) were compared before treatment and 1 month after treatment in both groups.
      Results  The clinical effect and electrocardiogram effect of the experimental group were significantly better than those of the control group (P < 0.05). After one month of treatment, the scores ofTCM symptoms in both groups were significantly lower than those before treatment, and the scores in the experimental group were significantly lower than those in the control group (P < 0.05). One month after treatment, the levels of HDL-C in both groups were significantly higher than those before treatment, while the levels of LDL-C, TG and TC were significantly lower than those before treatment, and the indexes in experimental group were significantly better than those in the control group (P < 0.05). One month after treatment, plasma viscosity, HCT and EAI levels in both groups were significantly lower than those before treatment, and the indexes in experimental group were significantly lower than those in the control group (P < 0.05). The incidence rate of adverse reactions in the experimental group was 9.52%, which showed no significant difference when compared to 7.94% in the control group (P>0.05).
      Conclusion  Yiqi Yangxin Huoxue Recipe can effectively relieve the clinical symptoms of patients with angina pectoris differentiated as type of deficiency of Qi and Yin complicated with blood stasis, which can improve blood lipid metabolism and hemorheology.

     

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