颈动脉超声联合血管内皮生长因子、基质金属蛋白酶-9、超敏C反应蛋白检测在动脉粥样硬化斑块稳定性中的应用分析

袁山旗; 赵红敏; 王晓叶; 张西安; 候鹏飞; 刘展会

doi:10.7619/jcmp.201917008

颈动脉超声联合血管内皮生长因子、基质金属蛋白酶-9、超敏C反应蛋白检测在动脉粥样硬化斑块稳定性中的应用分析

Application analysis of carotid ultrasound combined with detections of vascular endothelial growth factor, matrix metalloproteinase-9 and hypersensitive C-reactive protein in the stability of atherosclerotic plaque

摘要

摘要:
目的探讨颈动脉超声联合血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)检测在动脉粥样硬化斑块稳定性中的应用效果。
方法选取98例动脉粥样硬化患者, 均行颈动脉超声联合VEGF、MMP-9、hs-CRP检测，并以随访及磁共振检查为对照，比较颈动脉超声与颈动脉超声联合VEGF、MMP-9、hs-CRP检测结果，以及不同斑块类型患者血清VEGF、MMP-9、hs-CRP水平。
结果经随访及组织病理学发现, 98例动脉粥样硬化患者中，无斑块33例，稳定性斑块32例，易损性斑块33例。颈动脉超声联合VEGF、MMP-9、hs-CRP检测无斑块、稳定性斑块及易损性斑块的准确性均显著高于颈动脉超声检测(P < 0.05); 稳定性斑块患者血清VEGF、MMP-9及hs-CRP水平均显著高于无斑块患者，显著低于易损性斑块患者(P < 0.05)。
结论颈动脉超声联合VEGF、MMP-9、hs-CRP检测可准确明确动脉粥样硬化斑块性质，反映斑块稳定性及病变程度。

Abstract:
Objective To investigate the effect of carotid ultrasound combined with detections of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and hypersensitive C-reactive protein (hs-CRP) in the stability of atherosclerotic plaque.
Methods Totally 98 patients with atherosclerosis were conducted with carotid ultrasound and detections of VEGF, MMP-9 and hs-CRP. Taking the results of follow-up and magnetic resonance imaging as controls, the results of carotid ultrasound and carotid ultrasound combined with VEGF, MMP-9, hs-CRP were compared, and the serum levels of VEGF, MMP-9 and hs-CRP in patients with different plaque types were compared as well.
Results Follow-up and histopathological findings showed that among 98 patients with atherosclerosis, 33 cases had no plaque, 32 cases had stable plaque and 33 cases had vulnerable plaque. The accuracy of carotid ultrasound combined with VEGF, MMP-9 and hs-CRP in detecting non-plaque, stable plaque and vulnerable plaque was significantly higher than that of carotid ultrasound (P < 0.05). The serum levels of VEGF, MMP-9 and hs-CRP in patients with stable plaque were significantly higher than those without plaque, and was significantly lower than those with vulnerable plaque (P < 0.05).
Conclusion Carotid ultrasound combined with detection of VEGF, MMP-9 and hs-CRP can accurately determine the nature of atherosclerotic plaque and reflect the stability and degree of atherosclerotic plaque.

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