Objective  To analyze the clinical features of patients with multiple organ dysfunction syndrome (MODS) caused by severe heat stroke.

  Methods  Clinical data and measures for cluster therapy of 18 patients with MODS caused by severe heat stroke were retrospectively analyzed, and clinical efficacy was observed.

  Results  All the patients were characterized by high fever, the average temperature was (40.5±1.8) ℃, and inflammatory indicators such as white blood cell count (WBC), C reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) significantly increased with an abnormal rate over 65%. Fifteen patients met the criteria of systemic inflammatory response syndrome (SIRS), prothrombin time (PT) and activated partial thromboplastin time (APTT) significantly prolonged, D-Dimer level significantly increased, and the abnormal rate was more than 80%. A total of 70 injured organs were involved, and the circulatory system, kidney and coagulation system ranked the top three. After implementation of cluster therapy, the patients′organ dysfunction can be reversed in time and recovered quickly.

  Conclusion  Several mechanisms, such as heat injury, SIRS and coagulation dysfunction, are involved in the pathophysiological process of severe heat stroke. Cluster therapy is effective.