Objective  To explore effect of continuous renal replacement therapy for critically ill patients and nursing measures.

  Methods  A total of 80 patients who received continuous renal replacement therapy were selected, and were divided into two groups by odd-even methods. Patients in control group was given routine treatment and nursing, study group was given continuous renal replacement therapy and comprehensive nursing.

  Results  There were no significant differences in biochemical indexes such as creatinine, urea nitrogen, sodium, potassium and chlorine between the two groups before treatment (P>0.05). After treatment, there were significant differences in above indicators between the two groups (P < 0.05). There were no significant differences in blood gas indexes such as pH value, partial arterial oxygen pressurep(O₂), partial arterial carbon dioxide pressurep(CO₂), oxyhemoglobin saturation (SaO₂), and plasma actual bicarbonate (AB) between the two groups before treatment (P>0.05), and showed statistical differences in above indicators after treatment (P < 0.05). The success rate of rescue in the study group was better than that of the control group (P < 0.05). The incidence of early removal caused by equipment alarm in the study group was lower than that in the control group (P < 0.05).

  Conclusion  Continuous renal replacement therapy in the diagnosis and treatment of critically ill patients can significantly improve the biochemical and blood gas indicators of patients, improve the effectiveness of clinical diagnosis and treatment. Meanwhile, comprehensive nursing intervention can improve the success rate of rescue and reduce incidence of nursing accidents.