Objective  To explore the effect of milrinone injection in the treatment of hypertensive heart disease patients with heart failure and its influence on exercise tolerance.

  Methods  A total of 94 patients with hypertensive heart disease and heart failure admitted to our hospital were enrolled in the study. According to the random number table Method, they were divided into control group and observation group, with 47 cases in each group. Control group was given conventional treatment such as antihypertensive and anti-heart failure therapies, and observation group was given milrinone injection on the basis of control group. The effects and levels of serum brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) before and after treatment were compared between the two groups. The Yaeger Cardiopulmonary Function Test was used to evaluate the exercise tolerance before and after treatment, and the adverse reactions were recorded.

  Results  The effective rate in observation group was higher than that in control group (P < 0.05). After treatment, the serum BNP and cTnI levels in observation group were lower than those in the control group (P < 0.05). After treatment, the exercise time, maximum heart rate and maximum oxygen consumption and maximum exercise load in observation group were greater than those in control group (P < 0.05). There was no significant difference in the incidence of total adverse reactions between two groups (P>0.05).

  Conclusion  Milrinone injection can improve the treatment efficacy of hypertensive heart disease patients with heart failure, reduce myocardial damage and enhance exercise tolerance.