Objective  To evaluate the clinical effect of pulmonary surfactant (PS) combined with ventilator in the treatment of neonatal meconium aspiration syndrome (MAS).

  Methods  A total of 200 children with MAS admitted to our hospital were randomly divided into control group (n=100) and observation group (n=100). The control group received ventilator treatment, and the observation group received PS treatment on the basis of the control group. The pulmonary oxygenation function and incidence of complication were compared between the two groups.

  Results  After treatment, the pulmonary oxygenation function and blood gas analysis indicators were improved compared with the control group; the mean airway pressure(MAP) and fraction of inspiration oxygen(FiO₂) were lower than that of the control group at 12 and 24 h after treatment. The application time of ventilator was shorter than that of the control group. The incidence of ventilator-associated pneumonia and lung air leakage as well as mortality were lower than that of the control group, there were significant differences in two groups (P < 0.05).

  Conclusion  PS combined with ventilator for MAS has ideal therapeutic efficacy, which can improve lung function, and reduce the incidence of complications.