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脓毒症患者28 d死亡率的相关因素分析

Analysis in related factors of 28-day mortality in sepsis patients

    摘要
  • 摘要:
      目的  探讨影响脓毒症患者28 d死亡率的高危因素。
      方法  回顾性分析168例脓毒症患者临床资料，以确诊后28 d内死亡为终点事件，分析其相关影响因素。
      结果  年龄、急性生理与慢性健康Ⅱ(APACHEⅡ)评分、休克、C反应蛋白(CRP)、乳酸(Lac)均是脓毒症患者28 d死亡的独立危险因素(OR > 1, P < 0.05), 而VitD是其独立保护因素(OR < 1, P < 0.05); 上述因素受试者工作特征(ROC)曲线下面积(AUC)均明显大于参考线(P < 0.05)。
      结论  脓毒症患者28 d死亡率受年龄、APACHEⅡ评分、休克、CRP、Lac、VitD等因素独立影响。

     

    Abstract:
      Objective  To explore the high-risk factors of 28-day mortality in sepsis patients.
      Methods  The clinical materials of 168 patients with sepsis were retrospectively analyzed. Defining the death within 28 days after diagnosis as the end point, the related factors of death was analyzed.
      Results  Age, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, shock, C reactive protein (CRP), lactic acid (Lac) were the independent risk factors of 28-day mortality in sepsis patients (OR>1, P < 0.05), while VitD was an independent protective factor (OR < 1, P < 0.05). The values of area under curve (AUC) of receiver operating characteristic curve (ROC) of the factors mentioned above were significantly larger than the reference line (P < 0.05).
      Conclusion  The 28-day mortality of sepsis patients is independently affected by age, APACHE Ⅱscore, shock, CRP, Lac, and VitD.

     

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