高级检索

宫颈液基细胞学检查联合人乳头瘤病毒基因分型检测对宫颈病变的筛查意义

Significance of screening cervical lesionsby cytology examination combined with human papilloma virus genotyping

    摘要
  • 摘要:
      目的  探讨宫颈液基细胞学检查(TCT)、人乳头瘤病毒(HPV)检测与宫颈活检组织病理的关系。
      方法  回顾性分析130例妇女的TCT、HPV结果与宫颈活检病理为高级别病变的关系。
      结果  TCT结果为正常、不明确意义的不典型鳞状细胞(ASCUS)、低级别鳞状上皮内病变(LSIL)、高级别鳞状上皮内病变(HSIL), 其高级别病变阳性率分别为15.8%、22.2%、43.8%、100.0%, 差异有统计学意义(P < 0.05); TCT以ASCUS以上病变为阳性筛查宫颈高级别病变的敏感性为84.2%, 特异性为34.8%。HPV结果为阴性、阳性的高级别病变阳性率分别是6.7%、34.0%, 差异有统计学意义(P < 0.05); HPV阳性筛查高级别病变的敏感性为94.1%, 特异性为31.1%。TCT联合HPV检测结果为双阴、单阳、双阳的高级别病变阳性率为0%、16.7%、42.1%, 差异有统计学意义(P < 0.05); TCT联合HPV检测筛查高级别病变的敏感性为84.2%, 特异性为52.2%。
      结论  TCT联合HPV检测可以提高筛查宫颈高级别病变的特异性。

     

    Abstract:
      Objective  To explore the relationship between cervical cytology(TCT), human papillomavirus(HPV) tests and histopathology by cervical biopsy.
      Methods  The relationship between TCT, HPV Results and advanced histopathological changes confirmed by cervical biopsy in 130 women.
      Results  Out of theses patients, TCT tests revealed four results: normal cells, atypicalsquamous cells of undetermined significance(ASCUS), low-grade squamous intraepithelial lesion(LSIL), high-grade squamous intraepithelial lesion(HSIL), and the positive rates of HSIL were 15.8%, 22.2%, 43.8%, and 100.0%, respectively (P < 0.05).Taking lesions above ASCUS as positive standard of TCT screening, the sensitivity and specificity of HSIL were 84.2% and 34.8%, respectively.The positive rates of high grade cervical lesions with negative and positive HPV Results were 6.7% and 34.0%, respectively (P < 0.05).The sensitivity of high grade cervical lesions was 94.1%and the specificity was 31.1% in HPV positive screening.The positive rates of high-level lesions were 0%, 16.7%, and 42.1%, respectively, in high grade cervical lesions with double negative, single positive, and double positive Results by TCT combined with HPV tests(P < 0.05).The sensitivity and specificity of TCT combined with HPV screening for high-level lesions was 84.2%, 52.2%, respectively.
      Conclusion  TCT and HPV in combination can improve specificity of high-level lesions screening.

     

    • HTML全文
    • 参考文献(20)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回