Objective  To investigate the clinical effect of continuous renal replacement therapy on the treatment of patients with severe acute renal failure.

  Methods  Totally 70 patients with severe acute renal failure were divided into control group and treatment group, with 35 cases in each group. The control group was treated with intermittent hemodialysis, while the treatment group was treated with continuous renal replacement therapy. The clinical efficacy, improvement of renal function before and after treatment, complications, 1-year survival rate and mortality after surgery were compared between the two groups.

  Results  The total effective rate was 94.29% in the treatment group, which was significantly higher than 57.14% in the control group (P < 0.05). The incidence rate of complications in the control group was 40.00%, which was significantly higher than 5.71% in the treatment group (P < 0.05). After treatment, blood urea nitrogen (BUN) and serum creatinine (Scr) in the treatment group were significantly higher than those in the control group, and endogenous creatinine clearance (Ccr) was significantly lower than that in the control group (P < 0.05). After one year of treatment, the survival rate and mortality of the treatment group were significantly better than those of the control group (P < 0.05).

  Conclusion  Continuous renal replacement therapy can significantly improve the clinical efficacy and survival rate of patients with severe acute renal failure, improve renal function, and reduce the incidence rate of complications and mortality.