Objective  To investigate the effect of probiotics combined with Kangfuxin liquid in the treatment of patients with mild to moderate ulcerative colitis in active stage.

  Methods  A total of 64 patients with mild to moderate active ulcerative colitis were randomly divided into observation group and control group. Both groups were treated with conventional therapy, the control group was treated with bifidobacterium triple viable enteral capsule, while the observation group was treated with bifidobacterium triple viable enteral capsule combined with Kangfuxin liquid for retention enema. The therapeutic effect of the two groups was compared.

  Results  The total effective rate was 93.75% in the observation group, which was significantly higher than 81.25% in the control group (P < 0.05). After treatment, the scores of TCM syndromes in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the serum C reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), fibrinogen (FIB), D-dimer (D-D) in both groups significantly improved when compared with those before treatment (P < 0.05), and the indexes in the observation group were significantly better than those in the control group (P < 0.05). The incidence rate of adverse reactions was 15.63% in the observation group and 18.75% in the control group, and there was no significant difference between two groups (P>0.05).

  Conclusion  Probiotics combined with Kangfuxin solution can effectively relieve the clinical symptoms and improve the level of serological indicators in patients with mild to moderate ulcerative colitis in active stage.