Objective  To investigate the influence of colloidal bismuth pectin capsules combined with self-made Yiqi Changhua Regime on improvement of gastric function indexes in chronic atrophic gastritis (CAG) patients with intestinal metaplasia (IM).

  Methods  Totally 80 patients with CAG and IM were randomly divided into combined group and control group, 40 cases in each group. The control group was treated with colloidal bismuth pectin capsules, while the combined group was treated with colloidal bismuth pectin capsules and self-made Yiqi Changhua Regime. The clinical efficacy, Scores of TCM symptoms, pathological score of gastric mucosa and gastric function indicators pepsinogen Ⅰ(PG Ⅰ), pepsinogen Ⅱ(PG Ⅱ) were compared between the two groups before and after treatment.

  Results  The total effective rate of the combined group was significantly higher than that of the control group (P < 0.05). After treatment, the scores of TCM symptoms in both groups were significantly lower than those before treatment, and the combined group was significantly lower than the control group (P < 0.05). After treatment, the scores of gland atrophy and intestinal metaplasia in both groups were significantly lower than those before treatment (P < 0.05), and the combined group was significantly lower than the control group (P < 0.05). After treatment, the levels of PG I increased significantly and PG Ⅱdecreased significantly in both groups (P < 0.05), the level of PG Ⅰin the combined group was significantly higher than that in the control group (P < 0.05), and the level of PG Ⅱwas significantly lower than that in the control group (P < 0.05).

  Conclusion  Bismuthcolloidal pectin capsule combined with self-made Yiqi Changhua Regime is effective in the treatment of CAG patients with IM, which can significantly improve the pathological manifestations of gastric mucosa and effectively regulate the level of pepsinogen.