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血清同型半胱氨酸、胱抑素C及尿液清蛋白、尿β2微球蛋白水平对糖尿病肾病的临床价值

Clinical value of serum homocysteine, cystatin C, urinary albumin and urinary β2 microglobulin in diabetic nephropathy

    摘要
  • 摘要:
      目的  探讨血清同型半胱氨酸、胱抑素C、尿清蛋白、尿β2微球蛋白水平对糖尿病肾病的临床价值。
      方法  随机选取200例糖尿病肾病患者, 设为研究组; 以同样方法选取同期200名健康体检者，设为对照组。2组均检测血清同型半胱氨酸、胱抑素C、尿清蛋白、尿β2微球蛋白，并比较组间差异。
      结果  研究组确诊时血清同型半胱氨酸、胱抑素C、尿清蛋白、尿β2微球蛋白水平显著高于对照组体检时，且显著高于本组治疗后(P < 0.05); 研究组中，同型半胱氨酸、胱抑素C、尿清蛋白、尿β2微球蛋白联合检测阳性率为89.00%, 显著高于各项单独检测阳性率49.50%、65.00%、57.00%、67.50%(P < 0.05)。
      结论  临床联合检测血清同型半胱氨酸、胱抑素C、尿清蛋白、尿β2微球蛋白指标水平，有利于提升糖尿病肾病的诊断阳性率，更好地指导治疗方案的制订。

     

    Abstract:
      Objective  To investigate the value of serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin in diabetic nephropathy.
      Methods  A total of 200 diabetic nephropathy patients in our hospital were randomly selected as research group. In the same period, 200 healthy subjects were selected as control group. Levels of serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin were detected in both groups, and the differences between the two groups were compared.
      Results  The serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin levels in the study group at diagnosis were higher than that in the control group at physical examination and after treatment(P < 0.05). The positive rate of combined detection of homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin was 89.00%, which was higher than 49.50%, 65.00%, 57.00%, and 67.50%, respectively, of detection alone(P < 0.05).
      Conclusion  Clinical combineddetection of serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin is helpful to improve the positive rate of diagnosis of diabetic nephropathy and guide the formulation of treatment plan.

     

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