Objective  To compare the effect of painless colonoscopy and common colonoscopy on the incidence rate of intestinal perforation.

  Methods  Totally 116 patients with colonoscopy examination were divided into observation group (n=58) with painless colonoscopy and control group (n=58) with conventional colonoscopy according to coin tossing method. The clinical effect and incidence rate of intestinal perforation were compared between the two groups.

  Results  Before the examination, there were no significant differences in vital signs and oxygen saturation between the two groups (P>0.05). During the examination, the vital signs of the observation group were significantly lower than those of the control group (P < 0.05), but there were no significant differences in oxygen saturation and operation time between the two groups (P>0.05). The incidence rate of intestinal perforation in the observation group was significantly higher than that in the control group (P < 0.05). Satisfaction degree of the observation group was significantly higher than that of the control group (P < 0.05).

  Conclusion  Painless colonoscopy has less influence on the vital signs of patients and a higher satisfaction degree during clinical application, but the incidence rate of intestinal perforation is higher than that of conventional colonoscopy.