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不同危险因素的急性脑梗死患者血清超敏C反应蛋白、神经元特异性烯醇化酶含量的变化及其临床意义

Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors

    摘要
  • 摘要:
      目的  探讨不同危险因素的急性脑梗死(ACI)患者血清超敏C反应蛋白(hs-CRP)、神经元特异性烯醇化酶(NSE)含量的变化及临床意义。
      方法  选取20例健康对照者与68例急性脑梗死患者，根据危险因素将脑梗死患者分为单纯脑梗死组、脑梗死合并高血压病组、脑梗死合并糖尿病组。采用酶联免疫吸附实验测定血清中hs-CRP、NSE的浓度，比较不同危险因素脑梗死患者hs-CRP及NSE含量变化。采用美国国立卫生院卒中量表(NIHSS)评估神经缺损程度。
      结果  ACI患者入院血清hs-CRP、NSE浓度显著高于健康对照组(P < 0.01)。ACI患者中，脑梗死合并高血压组、脑梗死合并糖尿病组患者血清hs-CRP、NSE浓度显著高于单纯脑梗死患者(P < 0.05)。ACI患者血清hs-CRP、NSE浓度与NIHSS评分呈线性正相关。Pearson相关分析显示, ACI患者血清hs-CRP水平与NSE水平呈显著线性正相关(P < 0.05)。
      结论  急性脑梗死患者合并高血压病、糖尿病会加重血管炎性反应及神经功能损害。

     

    Abstract:
      Objective  To explore clinical significance and changes of serum high-sensitivity C reactive protein (hs-CRP) and neuron-specific enolase (NSE) in acute cerebral infarction (ACI) patients with different risk factors.
      Methods  Totally 20 healthy people and 68 patients with ACI were selected, and the ACI patients were divided into simple ACI group, ACI plus hypertension group and ACI plus diabetes group according to risk factors. The serum levels of hs-CRP and NSE were measured by ELISA, and the changes of hs-CRP and NSE in cerebral infarction patients with different risk factors were compared. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of neurological deficits.
      Results  The serum hs-CRP and NSE levels in ACI patients were significantly higher than those in control group at adnission (P < 0.01). In ACI patients, the serum hs-CRP and NSE levels in ACI plus hypertension group and ACI plus diabetes group were significantly higher than those in simple ACI group (P < 0.05). Serum hs-CRP and NSE levels in ACI patients were positively correlated with NIHSS scores. Pearson correlation analysis showed that serum hs-CRP level was positively correlated with NSE level in ACI patients (P < 0.05).
      Conclusion  Acute cerebral infarction patients may suffer more serious aggravate vasculitis and neurological impairment when complicated with hypertension and diabetes.

     

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