Objective  To explore clinical significance and changes of serum high-sensitivity C reactive protein (hs-CRP) and neuron-specific enolase (NSE) in acute cerebral infarction (ACI) patients with different risk factors.

  Methods  Totally 20 healthy people and 68 patients with ACI were selected, and the ACI patients were divided into simple ACI group, ACI plus hypertension group and ACI plus diabetes group according to risk factors. The serum levels of hs-CRP and NSE were measured by ELISA, and the changes of hs-CRP and NSE in cerebral infarction patients with different risk factors were compared. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of neurological deficits.

  Results  The serum hs-CRP and NSE levels in ACI patients were significantly higher than those in control group at adnission (P < 0.01). In ACI patients, the serum hs-CRP and NSE levels in ACI plus hypertension group and ACI plus diabetes group were significantly higher than those in simple ACI group (P < 0.05). Serum hs-CRP and NSE levels in ACI patients were positively correlated with NIHSS scores. Pearson correlation analysis showed that serum hs-CRP level was positively correlated with NSE level in ACI patients (P < 0.05).

  Conclusion  Acute cerebral infarction patients may suffer more serious aggravate vasculitis and neurological impairment when complicated with hypertension and diabetes.