新疆地区维吾尔族、汉族女性乳腺癌患者原发灶与同期腋淋巴结转移灶中雌激素受体、孕激素受体、C-erbB-2表达的研究

张继运; 张金星; 张华; 马斌林; 孙刚

doi:10.7619/jcmp.201910003

新疆地区维吾尔族、汉族女性乳腺癌患者原发灶与同期腋淋巴结转移灶中雌激素受体、孕激素受体、C-erbB-2表达的研究

Research on expressions of estrogen receptor, progesterone receptor and C-erbB-2 in primary lesions and contemporary axillary lymph node metastasis lesions between Uygur nationality and Han nationality female patients with breast cancer in Xinjiang area

摘要

摘要:
目的探讨维吾尔族、汉族女性乳腺癌患者原发灶与同期腋淋巴结转移灶中雌激素受体(ER)、孕激素受体(PR)、C-erbB-2表达的差异。
方法选取2015年1月—2017年12月新疆肿瘤医院及新疆兵团第七师医院180例维吾尔族女性乳腺癌患者及205例汉族女性乳腺癌患者，检测原发灶、同期腋淋巴结转移灶中ER、PR、C-erbB-2表达。
结果维吾尔族组ER、C-erbB-2在原发灶及同期腋淋巴结转移灶中有较好的一致性，差异无统计学意义(χ²=1.118、3.211, P=0.290、0.073), 维吾尔族组PR在原发灶及腋淋巴结转移灶中表达差异有统计学意义(χ²=5.959, P=0.015)。汉族组ER、PR、C-erbB-2在乳腺癌原发灶与同期腋淋巴结转移灶中的表达有较好的一致性，差异无统计学意义(P>0.05)。
结论维吾尔族组乳腺癌患者原发灶与同期腋淋巴结转移灶中PR表达存在不一致性，这可能是维吾尔族组乳腺癌患者预后差的因素之一。

Abstract:
Objective To explore the differences of estrogen receptor (ER), progesterone receptor (PR) and C-erbB-2 in primary lesions and contemporary axillary lymph node metastasis lesions between Uygur nationality and Han nationality female patients with breast cancer in Xinjiang area.
Methods Totally 180 Uygur nationality women with breast cancer and 205 Han nationality women with breast cancer from January 2015 to December 2017 in Xinjiang Tumor Hospital and the Seventh Division Hospital of Xinjiang Production and Construction Corps were selected and conducted with detection of ER, PR and C-erbB-2 in primary lesions and contemporary axillary lymph node metastases lesions.
Results There were better consistencies in ER and C-erbB-2 between primary lesions and contemporary axillary lymph node metastasis lesions in Uygur nationality group (χ²=1.118、3.211, P=0.290、0.073), but there was significant difference in PR between primary lesions and contemporary axillary lymph node metastasis lesions in Uygur nationality group (χ²=5.959, P=0.015). There were better consistencies in ER, PR and C-erbB-2 in primary lesions and contemporaryaxillary lymph node metastasis lesions in Han nationality group (P>0.05).
Conclusion Conclusion The inconsistency difference of PR expression between primary lesions and contemporary axillary lymph node metastasis lesions may be a factor of the poor prognosis of Uygur nationality women with breast cancer.

HTML全文

参考文献(14)

施引文献

资源附件(0)