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白介素-17、趋化因子10在儿童自身免疫性肝炎中的变化及意义

Change and significance of interleukin-17 and chemokine 10 in children with autoimmune hepatitis

    摘要
  • 摘要:
      目的  探讨白介素-17(IL-17)、趋化因子10(CXCL10)在儿童自身免疫性肝炎中的变化及意义。
      方法  选取80例儿童自身免疫性肝炎患儿为观察组，另选择同期本院接受体检的健康儿童60例作为对照组。比较2组相关生化指标和血清IL-17、CXCL10的表达，分析血清IL-17、CXCL10与儿童自身免疫性肝炎的相关性。
      结果  观察组丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、免疫球蛋白G(IgG)、IL-17、CXCL10均显著高于对照组(P < 0.05)。Pearson相关性分析显示，血清IL-17与ALT、AST、TBIL、IgG均呈显著正相关(P < 0.05), 血清CXCL10与ALT、AST、TBIL、IgG均呈显著正相关(P < 0.05), 血清IL-17、CXCL10与儿童自身免疫性肝炎的发生呈显著正相关(r=0.634、0.592, P < 0.05)。Logistic回归分析显示，血清IL-17、CXCL10均是儿童自身免疫性肝炎发病的独立危险因素(P < 0.05)。
      结论  儿童自身免疫性肝炎患儿血清IL-17、CXCL10的表达明显升高。

     

    Abstract:
      Objective  To explore the change and significance of interleukin-17(IL-17) and chemokine 10 (CXCL10) in children with autoimmune hepatitis.
      Methods  A total of 80 children with autoimmune hepatitis were selected as observation group, and 60 healthy children with physical examination in the same period were selected as control group. The relative biochemical indexes and the expressions of IL-17 and CXCL10 in serum were compared between two groups, and correlations between serum IL-17, CXCL10 and occurrence of autoimmune hepatitis were analyzed.
      Results  The levels of alanine aminotransferase (ALT), glutamate transaminase (AST), total bilirubin (TBIL), immunoglobulin (IgG), IL-17 and CXCL10 in the observation group were significantly higher than those in the control group (P < 0.05). The Pearson correlation analysis showed that serum IL-17 and CXCL10 were positively correlated with ALT, AST, TBIL and IgG (P < 0.05). There was a positive correlation between serum IL-17, CXCL10 and the occurrence of autoimmune hepatitis in children (r=0.634、0.592, P < 0.05). Logistic regression analysis showed that serum IL-17 and CXCL10 were the independent risk factors for autoimmune hepatitis in children (P < 0.05).
      Conclusion  The expressions of serum IL-17 and CXCL10 significantly increase in children with autoimmune hepatitis.

     

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