高级检索

口服维生素D在支气管哮喘患儿治疗中的辅助作用

Auxiliary effect of oral vitamin D in the treatmentof children with bronchial asthma

    摘要
  • 摘要:
      目的  探讨口服维生素D在支气管哮喘患儿治疗中的应用效果。
      方法  选取200例支气管哮喘患儿, 按照分层随机原则分为2组，对照组100例应用布地奈德治疗，观察组100例在对照组基础上采用口服维生素D辅助治疗，比较2组治疗后的肺功能、哮喘症状改善情况。
      结果  观察组治疗后的白介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平显著低于对照组(P < 0.05); 观察组哮喘病情控制有效率显著高于对照组(P < 0.05); 观察组治疗后的第1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)水平改善优于对照组(P < 0.05), 气促缓解、哮鸣音消失、啰音消失以及咳嗽消失的时间显著早于对照组(P < 0.05)。
      结论  口服维生素D辅助用于支气管哮喘的治疗中，可有效改善患儿的症状以及肺功能。

     

    Abstract:
      Objective  To evaluate the effect of oral vitamin D in the treatment of children with bronchial asthma.
      Methods  A total of 200 children with bronchial asthma enrolled in the hospital were divided into two groups according to the stratified randomized principle. The control group(n=100) were treated with budesonide, and the observation group(n=100) were treated with oral vitamin D. The improvement of lung function and asthma symptoms between the two groups after treatment were compared.
      Results  The levels of interleukin-2(IL-2) and tumor necrosis factor-α(TNF-α) in the observation group were lower than those in the control group (P < 0.05). The effective rate of asthma control was higher than that that in the control group (P < 0.05). After treatment, forced expiratory volume in one second(FEV1), peak expiratory flow(PEF) and forced ratio of expiratory volume in one second to forced vital capacity(FEV1/FVC) in the observation group had better improvement than that of the control group (P < 0.05). The time in relief of shortness of breath, the disappearance of wheezing, the disappearance of arpeggio and cough were shorter than the control group (P < 0.05).
      Conclusion  Vitamin D in the treatment of bronchial asthma can effectively improve the symptoms and lung function of children.

     

    • HTML全文
    • 参考文献(18)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回