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中等强度运动疗法联合抗抑郁药物治疗卒中后抑郁的疗效观察

Efficiency observation of moderate-intensity exercise therapy combined with antidepressants in the treatment of patients with post-stroke depression

    摘要
  • 摘要:
      目的  探讨中等强度运动疗法联合抗抑郁药物治疗卒中后抑郁的临床疗效。
      方法  将45例脑卒中后抑郁患者随机分为低强度运动疗法联合抗抑郁药物治疗组(低强度联合组)、中等强度运动疗法联合抗抑郁药物治疗组(中等强度联合组)、单用抗抑郁药物治疗组(单用药物组)，每组15例。治疗4周后，比较3组治疗前后汉密尔顿抑郁评分(HAMD)、日常生活能力评分(MBI)、运动功能评分(FMA)的变化。
      结果  治疗4周后，低、中等强度联合组HAMD评分、MBI评分及FMA评分均较治疗前显著改善(P < 0.05), 而单用药物组仅HAMD评分较治疗前显著改善(P < 0.05); 治疗4周后，中等强度联合组HAMD评分、MBI评分、FMA评分较低等强度联合组及单用药物组显著改善(P < 0.05)。
      结论  中等强度运动疗法联合抗抑郁药物治疗卒中后抑郁的疗效最佳。

     

    Abstract:
      Objective  To explore the clinical effect of moderate-intensity exercise therapy combined with antidepressants in the treatment of patients with post-stroke depression.
      Methods  Totally 45 patients with post-stroke depression were randomly divided into low-intensity exercise therapy combined with antidepressant treatment group (low intensity combination group), moderate-intensity exercise therapy combined with antidepressant treatment group (moderate-intensity combination group) and single antidepressant treatment group (single drug group), with 15 cases in each group. After 4 weeks of treatment, the changes of Hamilton Depression Scale (HAMD), Activity of Daily Life Score (MBI) and Motor Function Score (FMA) before and after treatment were compared among the three groups.
      Results  After 4 weeks of treatment, HAMD score, MBI score and FMA score in low-intensity and moderate-intensity combination groups were significantly better than those before treatment (P < 0.05), while only HAMD score in single drug group was significantly better than that before treatment (P < 0.05). After 4 weeks of treatment, HAMD score, MBI score and FMA score in moderate-intensity combination group were significantly better than those in low-intensity combination group and single drug group (P < 0.05).
      Conclusion  The effect of moderate-intensity exercise therapy combined with antidepressant is the best in treatment of patients with post-stroke depression.

     

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