Objective  To analyze the effect of valsartan combined with carvedilol intreating chronic heart failure (CHF) and its effect on the expression level of plasma brain natriuretic peptide(BNP).

  Methods  Seventy-nine CHF patients admitted to our hospital were divided into control group (n=39) and observation group (n=40) according to the random number table method. The control group was treated with valsartan, while the observation group was treated with valsartan combined with carvedilol. The levels of cardiac function and BNP expression were compared between the two groups.

  Results  The improvement of cardiac function in the observation group was better, and the BNP expression was lower after treatment than that in the control group(P < 0.05). During the treatment, there was no liver or kidney abnormality between the two groups, and there was no significant difference in the incidence of adverse reactions (P>0.05).

  Conclusion  Valsartan combined with carvedilol in the treatment of chronic heart failure has an ideal therapeutic effect, which can reduce the level of plasma brain natriuretic peptide expression.