Objective  To explore the effect of Naoxintong Capsule combined with aspirin and clopidogrel in the treatment of acute ischemic stroke.

  Methods  A total of 96 patients with acute ischemic stroke who were admitted in our hospital were selected as subjects. According to the random number table method, they were divided into control group(n=48) and observation group(n=48). The control group was treated with aspirin and clopidogrel, while the observation group was treated with Naoxintong Capsule on the basis of the control group. The treatment efficacy, blood uric acid (UA), B cell lymphoma-2 gene(Bcl-2), X protein related to Bcl-2(BAX), neurological function score of the two groups were observed.

  Results  The total effective rate of the observation group and the control group was 95.83% and 81.25%, respectively, and the difference was significant (P < 0.05). There were no significant differences in the levels of UA, BAX and BCL-2 between the two groups before treatment (P>0.05), the above indicators were significantly improved after treatment, and the observation group was better than the control group (P < 0.05). The modified Rankin Scale score(mRS) and National Institutes of Health Neurologic Impairment Scale (NIHSS) scores of the observation group showed significant between group differences(P < 0.05).

  Conclusion  Naoxintong Capsule combined with aspirin and clopidogrel are effective in treating acute ischemic stroke, which can improve neurological function and regulate UA, BAX and BCL-2 protein levels.