Objective  To analyze the clinical efficacy of levocarnitine combined with Yougui Capsule on oligospermia and asthenospermia in male patients and its adverse effects.

  Methods  Eighty male patients with oligospermia admitted to our hospital were randomly divided into study group and control group, with 40 cases in each group. The control group was treated with levocarnitine alone, and study group was additionally given Yougui Capsule. The total effective rate, incidence of adverse reactions, semen quality parameters and changes of sex hormones were compared between the two groups after 3 months of treatment.

  Results  The total effective rate, plasma testosterone (T) level, and follicle stimulating hormone (FSH) in the study group were 87.50%, (812.3±130.2) ng/dL, and (9.1±3.5) IU/L, respectively, which were superior to 65.0%, (778.4±113.2) ng/dL, (8.0±2.1) IU/L, in the control group(P < 0.05). The incidence rate of adverse reactions in the study group was significantly lower than that of the control group (2.50% vs. 20.00%, P < 0.05). The semen quality parameters of the study group were significantly better than the control group(P < 0.05).

  Conclusion  The combination of levocarnitine and Yougui Capsule can effectively improve the sex hormone level and sperm quality, improve the reproductive function, which have fewer adverse reactions, and is safe and reliable.