Effect observation of insulin pump combined with dipeptidyl peptidase-Ⅳ inhibitor on the treatment of newly diagnosed type 2 diabetes mellitus
-
摘要:目的 探讨胰岛素泵联合二肽基肽酶-Ⅳ(DPP-Ⅳ)抑制剂治疗新诊断2型糖尿病(T2DM)的效果。方法 将51例新诊断T2DM患者随机分为试验组(胰岛素泵联合DPP-Ⅳ抑制剂)与对照组(单用胰岛素泵)。治疗15 d后比较2组临床疗效。结果 治疗后, 2组血糖相关指标均显著改善(P < 0.05), 且试验组血糖控制显著优于对照组(P < 0.05)。试验组胰岛β细胞功能指数、C肽曲线下面积、胰岛素抵抗指数显著优于对照组(P < 0.05)。试验组胰岛素用量、血糖完全达标比例、血糖达标时间、体质量增加值均显著优于对照组(P < 0.01)。试验组低血糖发生率为8.00%(2/26), 对照组为12.00%(3/25), 2组差异无统计学意义(P>0.05)。治疗过程中, 2组均未发生严重低血糖事件以及肝、肾功能损害。结论 胰岛素泵联合DPP-Ⅳ抑制剂治疗新诊断T2DM的效果显著，能有效控制血糖，减轻胰岛素抵抗，减少体质量增加。Abstract:Objective To investigate the effect of insulin pump combined with dipeptidyl peptidase-Ⅳ (DPP-Ⅳ) inhibitor on the treatment of newly diagnosed type 2 diabetes mellitus (T2DM).Methods Totally 51 newly diagnosed patients with T2DM were randomly divided into experimental group (insulin pump combined with DPP-Ⅳ inhibitor) and control group (insulin pump alone). After 15 days of treatment, the clinical effect was compared between two groups.Results After treatment, the blood sugar related indexes in both groups significantly improved (P < 0.05), and the blood sugar control of the experimental group was significantly better than that of the control group (P < 0.05). The pancreatic β cell function index, area under curve of C-peptide and insulin resistance index in the experimental group were significantly better than those in the control group (P < 0.05). The dosage of insulin, the ratio of patients with blood sugar reaching the standard completely, the time of blood sugar reaching the standard and the increase value of body mass in the experimental group were significantly better than those in the control group (P < 0.01). The incidence rate of hypoglycemia was 8.00% (2/26) in the experimental group and 12.00% (3/25) in the control group, and there was no significant difference between the two groups (P>0.05). During the treatment, no severe hypoglycemic events and liver and kidney function damage occurred in both groups.Conclusion Insulin pump combined with DPP-Ⅳ inhibitor is effective in the treatment of newly diagnosed T2DM, which can effectively control blood sugar, reduce insulin resistance and weight gain.
-
-
表 1 2组患者治疗前后各项指标比较(x±s)
组别 时点 FBG/(mmol/L) 2 hBG/(mmol/L) HOMA-β(C-P) AUC(C-P) HOMA-IR(C-P) 试验组(n=26) 治疗前 12.92±1.23 20.12±2.61 0.07±0.02 9.11±2.35 3.9±1.6 治疗后 5.58±0.79*# 7.11±2.52*# 0.19±0.09* 13.18±3.12* 2.2±0.4*# 对照组(n=25) 治疗前 13.21±1.12 19.11±3.52 0.08±0.03 7.67±2.68 4.1±1.4 治疗后 8.61±2.04* 11.21±3.89* 0.18±0.07* 11.23±3.78* 3.4±0.7* FBG: 空腹血糖; 2 hBG: 餐后2 h血糖; HOMA-β(C-P): 以C肽评价的胰岛β细胞功能指数; AUC(C-P): 以C肽评价的曲线下面积; HOMA-IR(C-P): 以C肽评价的胰岛素抵抗指数。与治疗前比较, *P < 0.05; 与对照组比较, #P < 0.05。 
下载: 导出CSV
表 2 2组胰岛素用量、血糖完全达标比例、血糖达标时间、体质量增加值比较(x±s)[n(%)]
组别 n 胰岛素用量/(U/d) 血糖完全达标 血糖达标时间/d 体质量增加值/kg 试验组 26 29.89±3.90** 23(88.50)** 4.20±1.10** 1.60±0.60** 对照组 25 42.40±4.10 15(60.00) 8.40±2.80 4.20±1.40 与对照组比较, **P < 0.01。
下载: 导出CSV
-
[1] 陈灏珠. 内科学[M]. 8版. 北京: 人民卫生出版社, 2013: 1-54. [2] 王凯军, 梅询. 高胰岛素血症与动脉粥样硬化研究现状[J]. 实用临床医学, 2014, 9(10): 129-130. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ201301015.htm [3] 邢莉, 申虎威. 地特胰岛素加三餐前速效胰岛素与胰岛素泵短期强化治疗对2型糖尿病的疗效比较[J]. 中国糖尿病杂志, 2012, 20(2): 126-128. doi: 10.3969/j.issn.1006-6187.2012.02.012 [4] Ismail-Beigi F. Pathogenesis and glycemic management of type 2 diabetes mellitus: a physiological approach[J]. Arch Iran Med, 2012, 15(4): 239-246. http://www.ncbi.nlm.nih.gov/pubmed/22424044
[5] 谢艳红, 莫朝晖, 金萍, 等. 初诊2型糖尿病短期胰岛素强化治疗后胰岛β细胞功能的动态变化[J]. 中国糖尿病杂志, 2008, 16(4): 225-227. doi: 10.3321/j.issn:1006-6187.2008.04.010 [6] 陆浩, 钱菊英, 葛均波. 高胰岛素血症与型糖动脉粥样硬化[J]. 中国临床医学, 2008, 15(1): 35-38. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX200801013.htm [7] Müller W A, Faloona G R, Aguilar-Parada E, et al. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion[J]. N Engl J Med, 1970, 283(3): 109-115. doi: 10.1056/NEJM197007162830301
[8] Wajchenberg B L. beta-cell failure in diabetes and preservation by clinical treatment[J]. Endocr Rev, 2007, 28(2): 187-218. http://www.ncbi.nlm.nih.gov/pubmed/17353295
[9] 占美, 徐班, 吴逢波. 沙格列汀治疗2型糖尿病的Meta分析[J]. 中国循证医学杂志, 2012, 12(6): 708-710. doi: 10.3969/j.issn.1672-2531.2012.06.016 -
期刊类型引用(12)
1. 毕富玺，闫颖，马静. 基于脑肠轴理论探讨针刺治疗肾阴虚型绝经综合征伴焦虑障碍的临床疗效. 天津中医药. 2024(06): 754-758 . 
百度学术
2. 鲁芳. 针灸加耳穴贴压结合雌二醇片治疗更年期综合征疗效观察. 实用中医药杂志. 2024(09): 1799-1801 . 百度学术
3. 徐莹. 柴胡桂枝龙骨牡蛎汤加减结合针灸治疗不寐症的临床效果分析. 内蒙古中医药. 2024(11): 73-75 . 百度学术
4. 韩倩楠，陈必慧，朱海利. 围绝经期女性失眠的中西医治疗思路比较. 海南医学. 2023(01): 148-152 . 百度学术
5. 张燕，高嘉良，夏普. 柴胡桂枝龙骨牡蛎汤治疗心脏神经官能症临床观察. 深圳中西医结合杂志. 2023(18): 34-37 . 百度学术
6. 沈晓桦，卢根娣，蒋国静，胡丽，谈晓红. 引阳入阴推拿对剖宫产后心脾两虚证产妇睡眠障碍及负性情绪的影响. 实用临床医药杂志. 2022(09): 54-58 . 本站查看
7. 郭中建. 柴胡加龙骨牡蛎汤治疗永久性房颤伴失眠患者的效果. 中国民康医学. 2022(13): 77-79 . 百度学术
8. 李玉舸. 柴胡龙骨牡蛎汤加减治疗围绝经期失眠的临床研究. 医学食疗与健康. 2022(15): 33-35+193 . 百度学术
9. 冉固生，王毅. 酸枣仁汤加味结合针灸治疗围绝经期失眠临床研究. 河南中医. 2022(11): 1644-1647 . 百度学术
10. 王春华，朱人杰，董君伟. 鹿角龟芍汤联合盐酸帕罗西汀治疗围绝经期抑郁症的效果及对神经递质、生殖内分泌激素的影响. 临床误诊误治. 2022(11): 41-46 . 百度学术
11. 王鸣瑞，方朝晖，韩辉，丁小娟. 益肝血合酸枣仁汤加减治疗围绝经期妇女失眠对性激素水平及睡眠质量的影响. 湖南师范大学学报(医学版). 2021(04): 9-13 . 百度学术
12. 陈淼，史筱笑，安冬青. 桂枝汤类方治疗心系疾病的Meta分析. 河南中医. 2021(12): 1807-1814 . 百度学术
其他类型引用(8)
计量
- 文章访问数:
- HTML全文浏览量:
- PDF下载量:
- 被引次数: 20
苏公网安备 32100302010246号