Objective  To explore the effect of evidence-based nursing on toxicity and side effects of breast cancer patients undergoing chemotherapy.

  Methods  Forty-five patients with breast cancer treated in our department from January to March 2018 were selected as control group, receiving routine nursing. Forty-five patients with breast cancer treated by chemotherapy in our department from April to June 2018 were selected as observation group, given evidence-based nursing to prevent side effects on thebasis of routine nursing. The mastery of health knowledge of chemotherapy and related toxicity and side effects were compared between the two groups.

  Results  The scores of health knowledge in basic knowledge of chemotherapy, bone marrow suppression, digestive tract and dietary nutrition in the observation group were higher than that in the control group (P < 0.05). The incidence of gastrointestinal adverse reactions, bone marrow suppression and stomatitis in the observation group was lower than that in the control group (P < 0.05). The compliance of the observation group was higher than that of the control group (P < 0.05).

  Conclusion  Evidence-based nursing can increase the health knowledge of breast cancer patients undergoing chemotherapy, reduce toxicity and side effects, and improve their compliance with chemotherapy.