Objective  To investigate the effect of ultrasound-guided lumbar plexus-sciatic nerve block on perioperative oxidative stress response in elderly patients with hip replacement.

  Methods  A total of 79 elderly patients with hip replacement were divided into two groups. The control group was treated with general anesthesia, and the observation group was treated with ropivacaine for lumbar plexus-sciatic nerve block. The perioperative hemodynamics indexes and oxidative stress response indexes were compared between the two groups. The number of effective analgesic pump presses and the number of adverse reactions were recorded.

  Results  At the time points of before anesthesia (T₀), skin incision (T₁), 30 minutes after operation (T₂), at the end of operation (T₃) and 1 hour after operation(T₄), the hemodynamic indexes of the control group changed significantly, and the levels of indexes at T₁ were the lowest (P < 0.05). The hemodynamic indexes of the observation group did not change significantly with time, and there were no significant differences in indexes between each time point (P>0.05). The levels of serum C-reactive protein (CRP) and cortisol (COR) from T₁ to T₄ increased significantly with time in both groups (P < 0.05), norepinephrine (NE) level was the lowest at T₂ and increased significantly from T₃ to T₆ (P < 0.05). The changes of hemodynamic indexes and oxidative stress indexes in observation group were significantly smaller than those in control group at different time points (P < 0.05). Compared with the control group, the number of effective analgesic pump presses and cases with adverse reactions in the observation group were significantly less than those in the control group (P < 0.05).

  Conclusion  Ultrasound-guided lumbar plexus-sciatic nerve block has a high safety in hip replacement for elderly patients with femoral neck fracture, which can better stabilize hemodynamic parameters, inhibit oxidative stress reaction and reduce the using number of analgesic pump after operation.