Objective  To investigate the clinical characteristics and drug resistance of Klebsiella pneumoniae.

  Methods  A total of 148 patients with Klebsiella pneumoniae infection were selected as research subjects, and the clinical characteristics and drug resistance of Klebsiella pneumoniae were studied and compared with automatic bacterial identification and drug sensitivity analyzer.

  Results  Klebsiella pneumoniae mainly came from sputum, and its detection rate was significantly higher than other sources(P < 0.05). The resistance rates of Klebsiella pneumonia to piperacillin and ampicillin were significantly higher than that of other antibacterial drugs (P < 0.05). The infection rate of Klebsiella pneumoniae in ICU was the highest, which was significantly higher than that of neurological department (29.29% vs. 7.07%, P < 0. 05). The drug resistance of ESBLs producing bacteria and non-ESBLs producing bacteria to ampicillin and paracillin was basically the same, and there were no differences between the two groups (P>0.05). The resistance rate of ESBLs producing bacteria to ampicillin, paracillin, ceftazidime, ceftriaxone, cefepime, cefazo, gentamicin and levofloxacin was significantly higher than that of non-ESBLs producing bacteria(P < 0.05).

  Conclusion  Klebsiella pneumoniae infection commonly occurs and mainly originates from sputum with higher drug resistance, therefore, the reasonable and effective preventive measures should be taken to reduce its risk.