Abstract: Objective To explore the effect of multimodal analgesia combined with preemptive analgesia on perioperative pain control and sleep quality in elderly patients with intertrochanteric fracture.Methods A total of 100 elderly patients with femoral intertrochanteric factures were selected as treatment group,and 100 patients were selected as control group.The treatment group was treated with multimodal analgesia and preemptive analgesia,while the control group was treated with the conventional analgesia.The VAS score and the amount of tramadol at preoperative 4 8 h,2 4 h and 2 4 h,3 d,1 week,2 weeks after operation were compared between the two groups.The sleep quality of patients during hospitalization was evaluated by the PSQI score.The length of first time move for exercise and postoperative hospital stay were compared between two groups,and the postoperative Harris hip score at 2 weeks,3 months after treatment and adverse reactions were compared.Results The treatment group had a lower VAS score at preoperative 48 h,24 h and 24 h,3 d,1 week,2 weeks after operation when compared with control group (P ＜ 0.05).Tramadol dose in the control group was significantly higher than the treatment group (P ＜ 0.05),the PSQI score was significantly higher than the treatment group (P ＜ 0.05),the length of postoperative move for exercise was significantly longer than the treatment group (P ＜ 0.05).Harris hip score at 2 weeks after operation in the treatment group was significantly higher than that in control group (P ＜ 0.05),while 3 months after operation,the Harris hip score was similar between the two groups (P ＞ 0.05).The total incidence rate of adverse reactions were similar between the two groups (P ＞ 0.05).Conclusion Application of multimodal analgesia combined with preemptive analgesia is effective and safe in treatment of elderly patients with femoral intertrochanteric fracture,it can improve the sleep quality,promote the hip joint function recovery of patients in early stage.