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盐酸纳洛酮注射液对慢性阻塞性肺疾病伴呼吸衰竭患者炎症因子IL-6、IL-8、IL-18、TNF-α的影响

Influence of naloxone hydrochloride injection on levels of IL-6, IL-8, IL-18 and TNF-α in patients with COPD complicated with respiratory failure

    摘要
  • 摘要: 目的 探讨盐酸纳洛酮注射液对慢性阻塞性肺疾病伴呼吸衰竭患者炎症因子IL-6、IL-8、IL-18、TNF-α的影响.方法 将60例COPD伴呼吸衰竭患者通过随机数字表法分为对照组(n=30)和实验组(n=30),对照组采用常规治疗,实验组在对照组的基础上加用盐酸纳洛酮注射液进行治疗.结果 治疗后,实验组炎性因子IL-6、IL-8、IL-18、TNF-α以及血气指标p(CO2)的水平显著低于对照组(P＜0.05),而血气指标p(O2)和pH显著高于对照组(P＜0.05);治疗后实验组肺功能指标FVC、FEV1％和PEF显著高于对照组(P＜0.05);实验组住院时间显著短于对照组(P＜0.05);实验组治疗总有效率显著高于对照组(P＜0.05).结论 盐酸纳洛酮注射液治疗慢性阻塞性肺疾病伴呼吸衰竭疗效佳.

     

    Abstract: Objective To explore the influence of naloxone hydrochloride injection on levels of IL-6,IL-8,IL-18 and TNF-α in patients with COPD complicated with respiratory failure.Methods A total of 60 COPD patients with respiratory failure were randomly divided into control group (n =30) and experimental group (n =30).The control group was given conventional medical treatment,while the experimental group was treated with naloxone on the basis of the control group.Results After treatment,the inflammatory factors IL-6,IL-8,IL-18,TNF-and blood gas indicators p(CO2) in the experimental group were significantly lower than the control group (P ＜ 0.05),and blood gas indicators p (O2) and pH were significantly higher than the control group (P ＜ O.05).The pulmonary function indexes FVC,FEV1 ％ and PEF in the experimental group were significantly higher than those in the control group (P ＜ 0.05).The hospital stay in the experimental group was significantly shorter than the control group (P ＜ 0.05).The total effective rate of the experimental group was significantly higher than that of the control group (P ＜ 0.05).Conclusion Naloxone hydrochloride injection is effective in the treatment of COPD patients with respiratory failure.

     

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