Abstract: Objective To explore the application of change speed of lithotomy position in the patients with gynecological laparoscopic surgery.Methods A total of 120 gynecological laparoscopic surgery patients in our hospital were randomly divided into observation group and control group,pneumoperitoneum pressure of two groups was 11 mmHg.The change speed of lithotomy position in the control group was in 6 s,the observation group was ＞ 30 s,and the changes of hemodynamics and blood gas indexes were compared.Results SBP and DBP after pneumoperitoneum in the two groups were increased compared with that before pneumoperitoneum (P ＜ 0.05).The increase of DBP and SBP after pneumoperitoneum in the observation group was less than that in the control group (P ＜ 0.05).PETCO2 after pneumoperitoneum in the observation group showed no statistically significant compared with pneumoperitoneum before (P ＞ 0.05),but the control group had higher PETCO2 than that before pneumoperitoneum,there were statistically significant differences (P ＜ 0.05).The observation group and the control group had a tendency to rise in airway pressure after pneumoperitoneum,but no statistical significance between the two groups was found (P ＞ 0.05).Conclusion Prolonging change time of lithotomy position can reduce the influence of hemodynamics for the patients with gynecological laparoscopic operation,and it is beneficial to the recovery of lung function.