Abstract: Objective To observe the effect of evidence-based nursing on postoperative nausea and vomiting in patients with thyroid operation.Methods A total of 76 patients with thyroid surgery were divided into 2 groups.The control group was given routine care,while the observation group was given evidence-based nursing.The incidence rates of nausea,vomiting and satisfaction degree were compared.Results In the control group,the incidence rates of nausea and vomiting were 44.74％ and 34.21％,which were significantly higher than 15.79％ and 13.16％ in the observation group (P ＜ 0.05).In the control group,the scores of nursing attitude and skills,professional knowledge,the total satisfaction rate of nursing errors were significantly worse than the observation group (P ＜ 0.05).In the control group,the IL-6,COR,VAS after nursing significantly decreased (P ＜ 0.05),and SAS had no change (P ＞ 0.05).Mter nursing in the observation group,the VAS,SAS score decreased significantly (P ＜ 0.05),and IL-6,COR had no change (P ＞ 0.05).IL-6,COR,VAS in observation group after nursing and SAS score were significantly higher than those in the control group (P ＜ 0.05).Conclusion Evidence-based nursing can reduce the incidence rates of postoperative nausea and vomiting and improve the satisfaction degree of patients with thyroid surgery.