Abstract: Objective To study the impact of integrated nursing process in intravenous thrombolysis in patients with cerebral infarction in superacute period.Methods A total of 31 intravenous thrombolysis patients from January to December 2015 were as experimental group given integrated nursing process and 31 cases from May to December 2014 were as control group given conventional nursing,thrombolysis patients' behavioral life quality by NIHSS,dementia by MMSE and depression by CES-D before and after thrombolysis were compared.Results There was no significant different in experimental group and control group in NIHSS score,MMSE score and CES-D scores before thrombolysis;while there was statistically significance between the two groups in NIHSS scores after thrombolysis in 24 hours,in 15 days or in one month(P ＜0.05).There was no statistically significance between the two groups in MMSE scores after thrombolysis in 24 hours (P ＞ 0.05),but was statistically significant in 15 days after thrombolysis and one month (P ＜ 0.01).There was statistically significant difference between the two groups in CES-D scores in 24 hours,15 days and 1 month after thrombolysis (P ＜ 0.05).Conclusion Quality of care for the patients with acute cerebral infarction thrombolysis associates with their behavioral life quality,dementia and depression.Integrated nursing process improves their behavioral life quality,and relieves dementia and depression of patients with acute cerebral infarction thrombolysis.