Abstract: Objective To explore the effect of respiratory training on respiratory function and quality life of patients with advanced lung cancer during chemotherapy.Methods A total of 60 patients with advanced lung cancer during chemotherapy in our hospital were randomly divided into observation group and control group by computer group numbers method,with 30 cases in each group,given with EP chemotherapy for both groups.The control group was additionally given conventional nursing,and the observation group was given respiratory training based on the control group,and the change of respiratory function and life quality after intervention were compared.Results FVE1,FVE1/FVC,FVE1％ after exercise in the observation group was higher than that in the control group,the difference was statistically significant (P ＜ 0.05).The physical pain,social function,mental function and vitality after the exercise in the observation group were higher than that in the control group,the difference was statistically significant (P ＜ 0.05).Conclusion Respiratory training can improve the respiratory function and life quality of patients with advanced lung cancer during chemotherapy.