Abstract: Objective To explore effect of the chest pain center (CPC) reperfusion process nursing on success rate of patients with acute myocardial infarction.Methods A total of 442 ST segment elevation myocardial infarction cases with early percutaneous coronary interention (PCI) after intravenous thrombolysis were selcted as the research objects and were randomly divided into control group with conventional care and observation group with chest pain center reperfusion process nursing,admission to the balloon expansion time,average hospitalization days and the average hospitalization expenses,and patients'satisfaction,hospital mortality,success rate of PCI,incidence of nursing adverse events were analyzed.Results Observation group had less average hospitalization expenses,length of hospital stay and admission to the balloon expansion time than the control group (P ＜ 0.01);There were significant difference in incidence of nursing adverse events,the success rate of PCI and hospital mortality in two groups (P ＜ 0.05),and the nursing satisfaction in the control group was lower than the observation group (P ＜ 0.01).Conclusion Chest pain center reperfusion treatment processes applied in patients with myocardial infarction care can effectively reduce the hospitalization cost,save the time of hospitalization and medical resources,improve the survival rate of the patients and ameliorate the prognosis,so it is worth promoting and application in clinic.