Abstract: Objective To explore expressions and clinical significance of CDX2,COX-2 and VEGF in colon carcinoma tissues.Methods The expressions of CDX2,COX-2 and VEGF in colon carcinoma tissues of 62 cases and normal colon tissuesof 20 cases were detected by immunohistochemical SP methods.Relationships between clinical pathological features and CDX2,COX-2 andVEGF were analyzed.Results The positive expression rates of CDX2 in colon carcinoma tissues and normal colon tissues were 54.8％ and 95.0％ respectively,the positive expression rates of COX-2 in colon carcinoma tissues and normal colon tissues were 75.8％ and 20.0％,and the positive expression rates of VEGF in colon carcinoma tissues and normal colon tissues were 80.6％ and 25.0％.The positive expression rate of CDX2 in colon carcinoma tissues was significantly lower than that in normal colon tissues(P ＜ 0.05),the positive expression rates of COX-2 and VEGF in colon carcinoma tissues were significantly higher than those in normal colon tissues (P ＜ 0.05).The positive expressions of CDX2,COX-2 and VEGF in colon carcinoma tissues were related with invasive depth and lymph node metastasis (P ＜ 0.05).Spearman correlation analysis results showed that expression of CDX2 was negatively correlated with COX-2 and VEGF in colon carcinoma tissues (P ＜ 0.05),and COX-2 was positively correlated with VEGF in colon carcinoma tissues (P ＜ 0.05).Conclusion The expressions of CDX2,COX-2 and VEGF are closely related with the occurrence,development and prognosis of colon carcinoma.