Abstract: Objective To study and investigate the changes of serum VEGF,EGF,EPO,TPO and oxidative stress of patients with aplastic anemia.Methods A total of 54 patients with aplastic anemia were selected as observation group,and 54 healthy people were selected as control group.The serum VEGF,EGF,EPO,TPO,enzymatic antioxidant indexes and non-enzymatic antioxidant indexes of two groups were detected and compared,and the serum VEGF,EGF,EPO,TPO,enzymatic antioxidant indexes and non-enzymatic antioxidant indexes were compared in patients with different Camitta types and classifications in the observation group.The relationship between those serum indexes and patients with aplastic anemia were analyzed by the Logistic analysis.Results The serum VEGF and EGF levels of observation group were significantly lower than those of control group,while the serum EPO and TPO levels were significantly higher than those of control group,the serum enzymatic antioxidant indexes including TAC,SOD and CAT of observation group were significantly lower than those of control group,serum MDA was significantly higher than that of control group,serum non-enzymatic antioxidant indexes including MT,GSH,Zn and Se were significantly lower than those of control group,serum Cu was significantly higher than that of control group,and the serum VEGF,EGF,EPO,TPO,enzymatic antioxidant indexes and non-enzymatic antioxidant indexes of observation group with different Camitta types all had significant differences,and those serum indexes all had close relationship with the aplastic anemia (P ＜ 0.05).Conclusion The serum VEGF,EGF,EPO,TPO and oxidative stress of patients with aplastic anemia are in abnormal state,and these indexes all have close relationship with the disease.