Abstract: Objective To explore the statin therapy and dose selection in treatment of patients with acute coronary syndrome in acute stage.Methods A total of 120 patients with acute coronary syndrome in acute stage were selected and randomly divided into the group A (atorvastatin 20 mg),group B (atorvastatin 10 mg) and group C (routine treatment).The effect was compared.Results After treatment,the levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-L),and high sensitive C reactive protein (hs-CRP) significantly improved in the group A and group B (P ＜ 0.05).After 4 weeks and 8 weeks of treatment,the levels of TC,TG,LDL-C in group A were significantly lower than the other two groups (P ＜ 0.05),the hs-CRP was significantly lower than the other two groups (P ＜ 0.05),and the TC,LDL-C standard rate were significantly better than the other two groups (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between the group A and group B.After 8 months of follow up,the incidence rate of cardiovascular events in group A was significantly lower than the other two groups (P ＜ 0.05).Conclusion Early use of large doses of atorvastatin is effective in treatment of patients with acute coronary syndrome in acute stage,and it can achieve the anti-inflammatory and lipid lowering effects,and reduce the incidence rate of cardiovascular events.