Abstract: Objective To investigate the effect of nutritional intervention on the quality of life and nutritional status of esophageal cancer patients with concurrent radiotherapy and chemotherapy.Methods A total of 100 esophageal cancer patients with concurrent radiotherapy and chemotherapy in our hospital were equally divided into study group (cluster nutritional intervention) and control group (routine nutritional intervention) using random number table method.Quality of life scale (EORTC QLQ-C3.0) and body weight,the level of hemoglobin (HB),serum albumin (ALB) and white blood cell count (WBC) after radiotherapy and chemotherapy were compared.Results There was no significant difference on admission in different indicators (P ＞ 0.05).After radiotherapy and chemotherapy,overall health status,body weight,HB,ALB,WBC in the study group were all better than that of the control group (P ＜ 0.05).Conclusion Nutritional intervention can not only improve the quality of life of patients with esophageal cancer,but also enhance the nutritional status of patients,and it is worth of further study and application in clinical practice.