Abstract: Objective To investigate the influence of nursing intervention based on Roy adaption theory on improving mood disorder and neurological deficit in patients with stroke.Methods Nursing measures of 82 patients diagnosed with stroke admitted in our department from January to February 2015 and from April to May 2015 were retrospectively analyzed,and were divided into conventional group(n =41) and Roy group(n =41).Conventional group received conventional medical care and general rehabilitation exercise,and Roy group added comprehensive care for psychological intervention based on Roy adaption theory.After nursing intervention,mood disorder and neurological deficit were compared by self-anxiety scale (SAS),self-Rating Depression scale (SDS) and neurological deficits scale (CNS).Results There was no significant difference in SAS,SDS and CNS between conventional group and Roy group before nursing intervention (P ＞ 0.05),but the scores of SAS,SDS and CNS in Roy group were significantly lower than conventional group after nursing intervention (P ＜ 0.05) and decreased significantly (P ＜ 0.05),and conventional group showed no significant difference after nursing intervention (P ＞ 0.05).Conclusion The comprehensive care for psychological intervention based on Roy adaption theory can significantly improve mood disorder and neurological deficit of stroke patients,which is worthy of popularization.