普拉洛芬联合氟米龙对LASEK术后并发症的防治作用
Effect of pranoprofen combined with fluorometholone on prevention and treatment of post-LASEK complications
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摘要: 目的 探讨普拉洛芬与氟米龙联合应用对近视眼行准分子激光上皮下角膜磨镶术(LASEK)后角膜刺激症及角膜雾状浑浊(Haze)的防治作用.方法 选取行LASEK治疗近视患者110例(220眼),随机分为对照组与观察组,各55例(110眼).对照组术后单用氟米龙滴眼液,观察组在对照组基础上联用普拉洛芬,观察2组术视力恢复、后角膜刺激症状及Haze的发生情况.结果 2组术后视力恢复情况相当(P＞0.05);观察组术后1～3d的角膜刺激症状明显轻于对照组(P＜0.05);观察组术后不同时期Haze 0.5、1级的发生程度均低于对照组(P＜0.05或P＜0.01).结论 联合应用普拉洛芬与氟米龙能减缓LASEK术后早期的角膜刺激症状,控制Haze的发生.Abstract: Objective To explore the effect of pranoprofen combined with fluorometholone on the prevention and treatment of corneal irritation and Haze after laser assisted subepithelial keratomileusis (LASEK).Methods A total of 1 10 patients (220 eyes) with LASEK for treatment of myopia were selected and randomly divided into control group and observation group,55 cases (110 eyes) in each group.Control group was treated with single fluorometholone eye drops,on which basis observation group was added with pranoprofen after operation.The postoperative vision recovery and the occurrence of corneal irritation and Haze were observed in both groups.Results The postoperative vision recovery was equivalent in two groups (P ＞ 0.05).Observation group was evidently milder in corneal irritation after postoperative 1 ～ 3 d than control group (P ＜ 0.05),and was prominently lower in the occurrence severity of Haze in class 0.5 and 1 in different postoperative periods (P ＜0.05 or P ＜ 0.01).Conclusion Pranoprofen combined with fluorometholone can relieve early corneal irritation and control the occurrence of Haze after LASEK.
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